Drug-Drug Interactions

Reaction Phenotyping

• Human liver microsomes
  

• Human expressed cloned enzymes
  

CYP inhibition

• Human liver microsomes
  

• Human expressed cloned enzymes
  

Non-CYP Enzymes

• Phase II enzymes (UGTs, etc)
  

• Oxidases; flavin mono-oxidase (FMO), monoamine oxidase (MAO), molybdenum-cofactor (MoCo) – containing aldehyde oxidase, etc
  

• Hydrolases; esterases, amidases, phosphoamindases, etc
  

CYP induction

• Human hepatocytes in vitro
  

• Animal models in vivo