Drug Metabolism

Metabolic Profiling

• CYP Phase 1 metabolites
  

• Non-CYP metabolites
  

• Phase II metabolites
  

• Enterohepatic circulation of metabolites
  

• Electrophile testing in high throughput format
  

Metabolism models

• Whole animal profiling of tissues (blood, urine, feces, brain, lung, etc)
  

• Organ systems in vivo (bile cannulation or other)
  

• Isolated perfused organs or tissues or tissue slices
  

• Cells (hepatocytes),
  

• S-9 (liver) or microsomes (liver)
  

• Isolated Cloned CYPs
  

Partial or complete structure elucidation (with or without radioisotopes)

PharmOptima's drug metabolism capabilities include metabolic profiling, metabolism models and partial or complete structure elucidation with or without radioisotopes.  For additional information, please contact us.