Specialized In Vivo Techniques

Intratracheal Instillation in Rats 

Administration of test materials suspended in a small volume of vehicle via the trachea directly to the lung.  The advantage of this delivery is it avoids deposition in the nasal passages and/or the fur as can occur in nose-only or whole-body inhalation.  this method is particularly well suited for the administration of highly toxic or radioactive materials, since the dose is confined to a small volume thus eliminating the need for deconatmination of large pieces of equipment.

Intranasal Inhalation in Mice

• Administration of test material by the intranasal route is an effective, noninvasive technique for delivery to the upper and lower respiratory tract in mice.
  

• Tissue collection: lungs, nasal tissue
  

Intranasal Instillation in Rats

• Administration of test material to the upper respiratory tract in rats.
  

• Tissue collection: nasal mucosal linings
  

• Nasal wash