Ophthalmology

Studies completed

• Drug uptake in ocular tissues at selected times after topical dosing
  

• Formulation comparisons using topical delivery and analysis of anterior or posterior chamber tissues
  

• PK effects with prodrugs
  

• Effects of corneal epithelium on drug uptake
  

• Treatments routes including topical, injection, or systemic dosing
  

• Assays established for batches of compounds sent for monthly screenings
  

• Hundreds of different compounds screened
  

• Metabolism evaluated in ocular microsomes or tissues
  

• Analysis of analgesia/anesthesia effects in vivo
  

Trained scientists

• Specialized dosing: topical ocular and intravitreal injection
  

• Tissue collection: aqueous humor, vitreous humor, cornea, conjunctiva, lens, iris-ciliary body, trabecular meshwork,
  

  sclera, retina, choroid, optic nerve, and blood

Collaborators

• Area board certified veterinarian ophthalmologist to assist with specific procedures
  

• Experienced subcontractors for ocular safety studies
  

• Primate facility experienced in ocular work
  

Bioanalytical

• Experienced in homogenization and extraction of ocular tissues and fluids
  

• Established LC-MS methods for over 300 compounds
  

• Validated assays using cross validations with surrogate species and artificial matrices
  

• Analyzed metabolism of drugs/prodrugs in ocular tissues
  

• Licensed radioisotope lab; experience at mass balance, tissue distribution, and metabolism studies with radioisotopes
  

• Experience in GLP-validated assays for plasma, non-ocular tissues, and dosing solutions
  

• Assayed plasma and dosing solutions from regulated animal safety studies and clinical trials
  

• Able to execute GLP-bioanalytical for ocular animal safety and clinical trials