Drug-Drug Interaction

PharmOptima provides a range of services to investigate drug-drug interactions including:

Reaction Phenotyping
  • Human liver microsomes
  • Human expressed cloned enzymes
CYP inhibition
  • Human liver microsomes
  • Human expressed cloned enzymes
Non-CYP Enzymes
  • Phase II enzymes (UGTs, etc)
  • Oxidases
    • flavin mono-oxidase (FMO)
    • monoamine oxidase (MAO)
    • molybdenum-cofactor (MoCo) - containing aldehyde oxidase, etc
  • Hydrolases
    • esterases
    • amidases
    • phosphoamindases
CYP induction
  • Human hepatocytes in vitro

Drug-Drug Interaction