Ophthalmic Studies Completed

Studies completed

  • dose administration routes evaluated include
    • topical
    • intravitreal
    • subtenon
    • systemic dosing
  • drug uptake in ocular tissues at selected times after topical dosing
  • formulation comparisons using topical delivery and analysis of anterior and posterior chamber ocular fluids & tissues
  • prodrug ocular pharmacokinetics
  • test article efficacy versus VEGF induced retinal leakage
  • ocular allergic response efficacy
  • bioanalytical assays established for batches of compounds sent monthly for screenings
  • hundreds of ocular compounds screened

Efficacy Models

  • VEGF induced retinal vascular leakage (wet AMD)
  • blue light damage (dry AMD)
  • STZ induced diabetic retinopathy
  • laser induced CNV
  • LPS induced Uveitis
  • allergic response