In vivo Pharmacokinetics (PK)

PharmOptima drug discovery services offers evaluation of compounds in multiple species; such as mouse, rat, and rabbit.

PK services include:

  • bioavailability studies (po, sc, im, ip, intratracheal)
  • single dose and multiple dose PK studies
  • discovery liquid formulation development and optimization
  • cassette (n-in-1) PK for early discovery compound screening and decision prioritization
  • drug distribution in tissue/organ and body fluid and determination of blood and brain ratio for brain penetration
  • metabolic kinetics with active metabolites
  • PK study for design of dose and dose regimen in various rodent disease models
  • PK analysis using WinNonlin® (v.6.2.1)

In vivo Pharmacokinetics (PK) / Pharmacodynamics (PD)